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Phenylpropanolamine Hydrochloride Chewable Tablets

ZyVet Phenylpropanolamine Hydrochloride is indicated for the control of urinary incontinence in dogs.

Available in 25 mg, 50 mg, and 75 mg scored tablets
Pronunciation: fen-uhl-pro-puh-NOL-uh-meen hy-droh-KLOR-ide

ZyVet generic phenylpropanolamine hydrochloride chewable tablets (PPA) for dogs are indicated for the control of urinary incontinence due to urethral sphincter hypotonus.

This is the FDA's first approved generic phenylpropanolamine hydrochloride chewable tablets.1 Urinary incontinence because of urethral sphincter hypotonus can happen as dogs age and as the animal’s muscle in its urethra weakens and loses control over its ability to hold urine.

  • Artificial chicken flavoring
  • Scored chewable tablets 
  • Easy to administer
  • Canine urinary incontinence treatment

IMPORTANT SAFETY INFORMATION

Phenylpropanolamine Hydrochloride is a sympathomimetic amine, closely related to ephedrine, used to manage urinary incontinence in dogs caused by urethral sphincter hypotonus.

The most commonly reported side effects include vomiting, loss of appetite, diarrhea, excessive salivation, agitation, tiredness, vocalization, confusion, increased water consumption, weight loss, weakness, fever, panting, and reversible changes in skin color (flushing or bright pink). Less common but serious reactions may include hypertension, ataxia, proteinuria, behavioral changes such as anxiety and aggression, seizures, tremors, renal failure, urinary retention and heart arrhythmias. In some cases, death, including euthanasia, has been reported. Sudden death was sometimes preceded by neurologic signs, vocalization, or collapse.

Phenylpropanolamine Hydrochloride may cause elevated blood pressure and should be used with caution in dogs with pre-existing heart disease, high blood pressure, liver disease, kidney insufficiency, diabetes, glaucoma, or other conditions associated with high blood pressure. Its safety in dogs used for breeding purposes, during pregnancy, or in lactating bitches has not been established. Regular veterinary monitoring is crucial to minimize risks.

If your dog shows unusual symptoms, including restlessness or irritability, loss of appetite, persistence or worsening of incontinence, or other unusual signs, contact your veterinarian immediately. Refer to the prescribing information for complete details regarding adverse events, warnings, and precautions.

CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. 

For more safety information, please see full Prescribing Information.

Approved by FDA under ANADA # 200-787

Reference: 

  1. FDA approves first generic phenylpropanolamine hydrochloride chewable tablets for use in dogs. FDA. June 11, 2024. https://www.fda.gov/animal-veterinary/cvm-updates/Fda-approves-first-generic-phenylpropanolamine-hydrochloride-chewable-tablets-use-dogs?utm Accessed June 12, 2024.
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